Qingxiang (Allen) Guo 🧬
Qingxiang (Allen) Guo
(he/him)

Postdoctoral Scholar | Cancer Genomics & AI

Postdoctoral scholar at Northwestern University developing computational approaches for cancer genomics. My research integrates long-read sequencing, structural variant analysis, and deep learning to decode the regulatory complexity of cancer genomes.
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About me

I am a computational biologist and postdoctoral fellow in Dr. Rendong Yang’s lab at Northwestern University Feinberg School of Medicine. My research focuses on developing computational methods and machine-learning approaches for cancer genomics and transcriptomics, with a particular interest in long-read sequencing. I use technologies such as Oxford Nanopore sequencing to study structural variants, transcriptomic alterations, and other complex molecular events that are difficult to resolve with conventional approaches.

Much of my work is driven by practical problems that emerge from real genomic data. I am the lead developer of OctopuSV (Bioinformatics), an automated toolkit for multi-sample structural variant analysis. I have also contributed to DeepChopper, a genomic language model published in Nature Communications for identifying chimeric artifacts in nanopore direct RNA sequencing, and ScanNeo2 (Bioinformatics), a workflow for neoantigen detection. My broader work spans long-read DNA and RNA sequencing, cancer immunogenomics, regulatory genomics, and multi-omic analysis.

My early academic training gave me a foundation in algorithm development, comparative genomics, and multi-omic data analysis. My scientific perspective was further shaped by my time at Oregon State University in 2014, where Prof. Jerri Bartholomew’s mentorship strengthened my interest in genomics, evolution, and data-driven biological discovery.

To date, I have authored or co-authored 26 peer-reviewed publications, including eight first-author papers, with work published in Nature Communications, Science Advances, Bioinformatics, BMC Biology, and other journals.

I am especially interested in the intersection of AI, long-read sequencing, and biomedical genomics. My long-term goal is to develop computational approaches that make complex genomic and transcriptomic events easier to resolve, interpret, and connect to cancer biology, while continuing to build an independent research direction in this area.

Featured Publications
Genomic language model mitigates chimera artifacts in nanopore direct RNA sequencing featured image

Genomic language model mitigates chimera artifacts in nanopore direct RNA sequencing

DeepChopper is a genomic language model that removes nanopore dRNA-seq chimera artifacts from base-called reads with single-base precision, enhancing transcript annotation and gene …

yangyang-li
OctopuSV and TentacleSV: a one-stop toolkit for multi-sample, cross-platform structural variant comparison and analysis featured image

OctopuSV and TentacleSV: a one-stop toolkit for multi-sample, cross-platform structural variant comparison and analysis

OctopuSV standardizes ambiguous BNDs and enables advanced multi-sample SV set operations; TentacleSV provides an end-to-end automated SV analysis pipeline from raw reads to …

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Qingxiang (Allen) Guo
ScanNeo2: a comprehensive workflow for neoantigen detection and immunogenicity prediction from diverse genomic and transcriptomic alterations featured image

ScanNeo2: a comprehensive workflow for neoantigen detection and immunogenicity prediction from diverse genomic and transcriptomic alterations

ScanNeo2 is a fully automated pipeline for high-throughput neoantigen prediction from raw sequencing data, integrating diverse somatic alterations beyond SNVs/indels (e.g., …

richard-a.-schafer
Recent Publications